In the ND-ischemia group, SOD1 and SOD2 immunoreactivity in CA2/3 pyramidal cells was significantly decreased to about 79% and 70%, respectively, of the ND-sham group at 1 day after tGCI, and their immunoreactivity was not significantly changed until 5 days post-tGCI (Figure 8Bb′–Bd′, D and Figure 10Bb′–d′, D). This evidence concerns the gene SOD1 and ischemia.