In the HFD-ischemia group, SOD1 and SOD2 immunoreactivity in CA1 pyramidal cells was significantly decreased from 1 day after tGCI, and, at 5 days after tGCI, SOD1 and SOD2 immunoreactivity was rarely observed in CA1 pyramidal cells due to their death (Figure 8Af–Ah, C and Figure 10Af–Ah, C). The gene discussed is SOD1; the disease is ischemia.