In the HFD-ischemia group, SOD1 and SOD2 immunoreactivity was gradually decreased with time, and, at 5 days after tGCI, SOD1 and SOD2 immunoreactivity was very low due to the damage of CA2/3 pyramidal cells (Figure 8Bf′–Bh′, D and Figure 10Bf′–Bh′, D). The gene discussed is SOD2; the disease is ischemia.