In the ND-ischemia group, SOD1 and SOD2 immunoreactivity in CA1 pyramidal cells was significantly decreased to about 69% and 67%, respectively, of the ND-sham group at 1 day after tGCI (Figure 8Ab, C and Figure 10Ab, C), and, at 2 days after tGCI, SOD1 and SOD2 immunoreactivity was more decreased (Figure 8Ac, C and Figure 10Ac, C). The gene discussed is SOD1; the disease is ischemia.