The expression of LKB1 was significantly associated with high histological grade (among LKB1 positive, grade 1&2 = 44.5%, grade 3 = 55.5%; among LKB1 negative, grade 1&2 = 59.2% and grade 3 = 40.8%, p = 0.01).However there was no statistically significant correlation with tumour size(among LKB1 positive, <3 cm = 81.7% and among LKB1 negative, <3 cm = 75.6%, p = 0.15) and axillary lymph node status (among LKB1 positive:, stage 1&2 = 87.1%, stage 3 = 12.9%, among LKB1 negative, stage 1&2 = 89.5%, stage 3 = 10.5%, p = 0.41). The gene discussed is STK11; the disease is neoplasm.