After hypoglycemia, due to glutamate and zinc release, elevated poly adenosine diphosphate (ADP) ribose polymerase (PARP) activation leads to energy depletion, lack of cytosolic Nicotinamid-Adenin-Dinukleotid (NAD), and therefore the inability to metabolize glucose even after it has been resupplied [33]. The gene discussed is PARP1; the disease is Hypoglycemia.