TLR4 and mastitis: By the way, the chlorogenic acid, oleanolic acid [50], botulin [51], and emodin had also been reported about their anti-inflammatory activities: chlorogenic acid could attenuate the LPS-induced mice mastitis by inhibiting the TLR4-mediated NF-κB pathway [52], emodin could relieve NLRP3 inflammasome activation, leading to decreased secretion of IL-1β and blocking of the inflammasome-induced pyroptosis [53], indicating that they may take responsibility for the anti-inflammatory activities as well.