HIF1A and cancer: However, the intracellular ascorbate content in many aggressive cancers may be suboptimal for the effective HIF-1 control [52,53,54], which can potentially be remediated by administration of pharmacological doses of vitamin C. Upregulation of HIF-1 and the hypoxia-like transcription response by two frequently used hypoxia mimetics cobalt and nickel has been suppressed by the supplementation with AA [55,56].