This concept was directly tested in the study of colon cancer cells overexpressing GLUT-1 due to the presence of activating mutations in KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) or BRAF (B-Raf proto-oncogene, serine/threonine kinase) oncogenes [65]. Here, BRAF is linked to malignant colon neoplasm.