Consistently, our results showed that FAM64A expression was correlated with OS in patients with pancreatic cancer, and the potential mechanism may be related with mitotic spindles, myc targets, MTORC1 signaling, G2M checkpoint, E2F targets, DNA repair, glycolysis and unfolded protein response as GSEA identified. The gene discussed is PIMREG; the disease is pancreatic neoplasm.