However, immunohistochemical analysis revealed that high EBV-CN significantly correlated with positive expression of PD-L1 in cancer cells (P = 0.015), while no correlation was observed with expression of PD-L1, CD8 and PD-1 in stromal immune cells or amplification of PD-L1 gene in cancer cells (Table 1). The gene discussed is CD274; the disease is cancer.