Positive feedback between Fgf10 and Fgfr2-IIIb has previously been reported during salivary gland development [15], and in nonmalignant tumors, Fgf7-mediated FGFR2-IIIb expression is thought to play a tumor-suppressive role by promoting epithelial differentiation [23,39]. Here, FGF7 is linked to neoplasm.