The impact of insulin resistance on the stromal microenvironment in the liver during injury is poorly understood [5], as is the role played by IRS proteins in regulating HSC biology, which involves injury-dependent cycles of myofibroblast activation and cell clearance during so-called "fibrogenic reversion." The model we present to explain impaired stromal induction of Fgf7 in the Irs2−/− mice (Fig 10) incorporates how IRS2 influenced fibrogenic reversion and survival of HSCs—only one of several FGF7-expressing stromal subpopulations that respond to DDC injury. This evidence concerns the gene IARS1 and Insulin resistance.