Our discovery that IRS2 silencing in HSCs also promoted fibrogenesis while limiting hepatocyte differentiation and FGFR2-IIIb expression in coculture recapitulated the increase in liver fibrosis and reduced Fgf7/Fgfr2-IIIb expression described in Irs2−/− mice during DDC treatment. Here, IRS2 is linked to Hepatic fibrosis.