TIAM1 and colorectal cancer: Such functions may be conserved, since the drosophila homolog still life/Tiam1 and C. elegans TIAM-1/GEF function during synaptic and, axonal patterning downstream of the netrin receptor UNC-40/DCC (Deleted in Colorectal Cancer), respectively (Sone et al., 1997; Demarco et al., 2012).