Furthermore, our meta‐analysis showed that high expression of tumor‐suppressor circRNAs was significantly associated with better clinical parameters (tumor size: OR = 0.56, 95%Cl: 0.33‐0.96; TNM stage: OR = 0.68, 95%Cl: 0.58‐0.81; differentiation grade: OR = 0.69, 95%Cl: 0.56‐0.85; vascular invasion: OR = 0.48, 95%Cl: 0.32‐0.74), whereas there were no significant relationships between high tumor‐suppressor circRNAs expression and other clinicopathological parameters including age, gender, liver cirrhosis, serum AFP, and HbsAg‐positive. Here, AFP is linked to neoplasm.