AFP and neoplasm: A significant association between high expression of oncogenic circRNAs and poor clinicopathological characteristics (tumor size: OR = 1.82, 95%Cl: 1.39‐2.38; TNM stage: OR = 2.07, 95%Cl: 1.51‐2.84; differentiation grade: OR = 1.89, 95%Cl: 1.48‐2.42; vascular invasion: OR = 1.83, 95%Cl: 1.34‐2.53; liver cirrhosis: OR = 1.52, 95%Cl: 1.17‐1.97; lymph node metastasis: OR = 2.83, 95%Cl: 1.77‐4.52; distant metastasis: OR = 3.50, 95%Cl: 1.51‐8.12; serum AFP: OR = 2.07, 95%Cl: 1.63‐2.64; HbsAg‐positive: OR = 1.65, 95%Cl: 1.24‐2.22) was observed in our study.