Prostate cancer is the most common malignant tumor and a leading cause of cancer‐related death in men worldwide.1 The prostate cancer burden in Chinese men has continuously increased due to increased screening based on blood prostate specific antigen (PSA) test, altered lifestyles and the aging of society.2 Radical prostatectomy (RP) is the first choice for the management of localized prostate cancer (LPCa). Here, KLK3 is linked to prostate cancer.