IRF4 and Miyoshi myopathy: In other words, MM is developed from an underlying precursor state, which is related to a series of cloning sequence evolution and a complex genetic background including deregulation of c-MAF, cyclin D1/D2, IRF4, and c-MYC, as well as mutations of TP53, CDKN2C, K-/N-RAS, and FAM46C [9, 10].