CDK8 and malignant colon neoplasm: Thus, in addition to its role as a CRC oncogene in driving Wnt/β–catenin signaling in invasive colon cancers, CDK8 acts as a tumor suppressor presumably in early stages of intestinal tumorigenesis (Meijer et al., 1998; Firestein et al., 2008; McCleland et al., 2015).