Also, a similar behavior has been seen regarding var gene expression in parasites infecting naïve patients compared to different isolates from high endemic populations in Africa, as naïve patients have not had the complete repertoire of antibodies to resist parasite infection and have not been able to enforce very strong immune selectivity against erythrocyte membrane protein 1 (Pf EMP1) encoded by such var genes (Abdi et al., 2016). Here, EMP1 is linked to infection.