CHI3L1 and metastatic malignant neoplasm in the lymph nodes: Both of these markers are significantly correlated with higher histologic grade, stage, lymph node metastases, myometrial invasion, and cervical involvement in patients with EC(6,7,8).YKL-40 (Human Chitinase-3-like protein 1) is a glycoprotein that belongs to the chitinase family.