The etiology of the increased ACTH secretion may be due to ectopic Corticotropin-Releasing Hormone (CRH) production as expression of CRH has been reported in advanced melanoma cells [191] and Cushing’s syndrome due to ectopic CRH secretion has been reported [192]. This evidence concerns the gene CRH and Cushing syndrome due to macronodular adrenal hyperplasia.