There were 7 cases of polyglandular endocrinopathies involving thyroiditis - plus anterior hypopituitarism [31, 123, 126]; plus primary adrenal insufficiency [126]; plus pituitary adrenocorticotrophic hormone (ACTH)-dependent Cushing’s syndrome and anterior hypopituitarism [127]; plus hypoparathyroidism [122]; and plus type 1 diabetes mellitus [128, 130]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.