The patient can present with symptoms and biochemical changes of two endocrine glands in sequence - thyroiditis and type 1 diabetes mellitus [130], hypoparathyroidism and thyroiditis [122], thyroiditis and ACTH-dependent Cushing’s syndrome [127], and primary hypothyroidism and isolated ACTH deficiency [93]. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.