Moreover, the analysis of oxidative stress biomarkers including enzymatic antioxidant defenses (CAT, SOD, and GPX) and oxidative damage antioxidants (protein carbonyls levels and lipoperoxidation), all measured spectrophotometrically in whole blood of 20 DS patients and 18 healthy controls, showed an increase in the SOD and CAT activities and a decrease in protein carbonyls levels in DS individuals, revealing a systemic prooxidant status in the blood of DS patients. Here, CAT is linked to Dravet syndrome.