Both the sulfated chitosan (SCS) and the sulfated benzaldehyde chitosan (SBCS) were investigated to significantly inhibit cell proliferation through induction of apoptosis and blockade of the FGF-2-induced phosphorylation of extracellular signal-regulated kinases (ERK) in the human breast cancer cell lines MCF-7 cells [47]. Here, FGF2 is linked to breast carcinoma.