Y. Xu and coworkers (2009) showed that chitosan nanoparticles (CNP) could inhibit the growth of human hepatocellular carcinoma through a mechanism of CNP-mediated inhibition of tumor angiogenesis that was associated to impaired levels of vascular endothelial growth factor receptor 2 (VEGFR2) [17]. Here, KDR is linked to hepatocellular carcinoma.