To further investigate whether UBE2C-regulated ZEB1/2 expression affects DDP-resistant cell senescence, invasiveness, and EMT in DDP-resistant NSCLC cells, we cotransfected UBE2C and siZEB1 or siUBE2C and ZEB1 into A549/DDP cells and then treated the cells with DDP and conducted colony formation (Figure 5(a)), SA-β-gal staining (Figure 5(b)), wound-healing (Figure 5(c)), and Matrigel invasion assays (Figure 5(d)). Here, ZEB1 is linked to non-small cell lung carcinoma.