In summary, UBE2C plays a critical role in decreasing the sensitivity to cisplatin, inhibiting cell senescence, and promoting cell proliferation, migration, and invasion via promoting the promoter activity of ZEB1/2; ZEB1/2 upregulates the expression of antidrug genes, ABCG2 and ERCC1, to induce DDP resistance in NSCLC cells (Figure 6(j)). Here, ERCC1 is linked to non-small cell lung carcinoma.