However, some tumor cells can escape and survive this immune system attack by various mechanisms including loss of tumor antigens; downregulating the major histocompatibility complex (MHC) from the surface; altering the tumor microenvironment by recruiting regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages; upregulating inhibitory receptors on T cells, or upregulating inhibitory ligands on tumor cells [9–11]. Here, HLA-C is linked to neoplasm.