In the study, treatment with either the anti-CTLA-4 antibody or tumor lysate-pulsed DCs resulted in an increased number of CD8+ T lymphocytes, inhibition of primary and metastatic lesion growth, prolonged survival, reduced number of regulatory T lymphocytes, and increased levels of serum IFN-γ, and the combination of these treatments enhanced the systemic immune response. This evidence concerns the gene CTLA4 and neoplasm.