In a study of high-dose IL-2 treatment in relapsed pediatric sarcoma, two of the four patients with osteosarcoma showed a complete response, although severe side effects were observed, including increases in white blood cells (WBC), creatinine, γ-glutamyltransferase, C-reactive protein, glucose, and body weight and decreases of red blood cells, platelets, protein, albumin, and cholinesterase [37]. The gene discussed is IL2; the disease is osteosarcoma.