Pathogenic mutations in genes that regulate RHO trafficking such as CRB1 (Crumbs in fly) also cause retinitis pigmentosa in humans and have also been shown to mediate retinal degeneration in Drosophila (O’Tousa, 1992; Li et al., 1994; den Hollander et al., 1999; Pellikka and Tepass, 2017). Here, RHO is linked to retinitis pigmentosa.