This approach has been used to study Amyloid Precursor Protein (AD) (Greeve et al., 2004), Aβ42 (AD) (Zhao et al., 2010), α-Synuclein (PD) (Chen and Feany, 2005; Roy and Jackson, 2014), Huntingtin (HD) (Jimenez-Sanchez et al., 2015), Tau [Frontotemporal Dementia (FTD)] (Frost et al., 2014), Superoxide Dismutase 1 (ALS) (acp:c8Sahin et al.Şahin et al., 2017), Ataxin-1 (SCA1) (Shiraishi et al., 2014), and C9orf72 (ALS/FTD) (Mizielinska et al., 2014) in the fly nervous system using the GAL4/UAS binary expression system (Brand and Perrimon, 1993). The gene discussed is APP; the disease is amyotrophic lateral sclerosis.