IFNB1 and neoplasm: On the other hand, radiotherapy doses of ≥12 Gy have been shown to attenuate radiotherapy-induced tumor immunogenicity through the induction of DNA exonuclease TREX1 (Three prime repair exonuclease 1), which degrades cytosolic dsDNA, thereby preventing cGAS/STING mediated induction of interferon beta (IFNβ) (119).