The largest study among those is the PACIFIC study, a multicenter randomized controlled trial comparing the use of PD-L1 inhibitor durvalumab as consolidation therapy following definitive chemoradiation in stage III NSCLC which showed a median progression free survival of 16.8 months compared to 5.6 months with placebo and an acceptable toxicity profile, resulting in prompt FDA approval of the adjuvant use of durvalumab for stage III NSCLC patients (147). This evidence concerns the gene CD274 and non-small cell lung carcinoma.