Fractionated lower doses (8 Gy*3) induced the production of IFN-I stimulated genes in mice followed by enhanced number of CD8α+ tumor infiltrating DCs (with high CD70) within the tumors and IFNβ in TSA cells in vitro but interestingly 20 Gy did not in part through in the induction of Trex1 by high-dose single fraction RT. Here, IFNB1 is linked to neoplasm.