The model of “exerkines” is promisingly supported by the discovery of apelin as a powerful peptide able to prevent sarcopenia (Vinel et al., 2018) as well as other myokines like irisin, IL-6 and IL-8 playing a beneficial role in cell adaptation in response to exercise (Díaz et al., 2018). The gene discussed is CXCL8; the disease is sarcopenia.