FFAs might substantiate insulin resistance, leading to lysosomal instability with leakage of cathepsin B and induction of the IKKβ/NF-κB pathway; alternatively, the caspase-1-IL-1β/IL-18 pathways might be activated through the NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome (Tilg et al., 2017). Here, IKBKB is linked to Insulin resistance.