INS and Insulin resistance: Experiments measuring hepatic DAGs content and hepatic insulin sensitivity in humans have indicated that DAGs strongly correlate with hepatic insulin resistance (Kumashiro et al., 2011; Ter Horst et al., 2017), whereas other potential mediators of hepatic insulin resistance (such as ceramides) show an inconsistent relationship (Luukkonen et al., 2016; Ter Horst et al., 2017).