While the clear concordance in high-affinity genomic CHD8 interactions suggests common regulatory functions across cell types, it remains to be examined whether the observed dysregulation of neurodevelopmental disorder-relevant neuronal genes is related to context-dependent CHD8 regulatory activity in the brain given the current cellular heterogeneity and technical challenges existing with available CHD8 ChIP-seq. Here, CHD8 is linked to neurodevelopmental disorder.