ADIPOR1 and Alzheimer disease: These observations were further corroborated by another recent study showing that gene-therapy induced suppression of AdipoR1 also produces an AD-like phenotype, which includes impaired spatial memory and learning, increased levels of Aβ aggregates and hyperphosphorylated tau, insulin signaling dysfunction, neuroinflammation and neurodegeneration markers (Kim et al., 2017).