Interestingly, a study in post mortem human brains also revealed intense immunostaining for AdipoR1 in the nucleus basalis magnocellularis (NBM) (Psilopanagioti et al., 2009), a small structure rich in cholinergic neurons projecting diffusely to the whole neocortex and other brain areas, and that is severely affected in AD (Liu A.K. et al., 2015). This evidence concerns the gene ADIPOR1 and Alzheimer disease.