For instance, increased levels of proinflammatory adipokines such as interleukin (IL)-1β, IL-6, TNFα and leptin, and decreased levels of anti-inflammatory adipokines, such as adiponectin, in obesity produce a chronic state of low-grade inflammation which promotes the development of insulin resistance and type-2 diabetes, hypertension, atherosclerosis and other cardiovascular diseases, and some types of cancer (Friedemann et al., 2012; Odegaard and Chawla, 2013; Hotamisligil, 2017). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.