INS and Cognitive impairment: Impaired insulin signaling is well documented both in human AD patients and in a variety of AD animal models (Steen et al., 2005; Bomfim et al., 2012; Talbot et al., 2012) and is considered an important mechanism for neuronal dysfunction and cognitive impairment in AD (Ferreira et al., 2014; Vieira et al., 2018) Synaptotoxicity of Aβ oligomers is accompanied by insulin receptor dysfunction in vitro and in vivo and can be prevented by treatment with insulin sensitizing drugs and by insulin itself (De Felice et al., 2009; Bomfim et al., 2012; Batista et al., 2018).