U2AF2 and myeloproliferative neoplasm: We observed that Dnmt3aR878H/+Npm1cA/+ MDS/MPD was associated with mutations in the tumor suppressor Cux1, previously shown to drive MDS and MDS/MPD [31] and in the RNA splicing genes Rbm10 and U2af2 (Fig. 4i, Table S3).