Young adults had greater total influenza-specific CD4 T cell reactivity when quantified by IFNγ production, with about 4.8-fold more total IFNγ+ CD69+ CD4 T cells when compared to children when all specificities were summed (total of 965 IFNγ+ CD69+ cells per million CD4 T cells in adults versus 201 in children). This evidence concerns the gene CD69 and influenza.