In order to obtain a suitable mouse model for investigation of stem cell therapy in ALS that would also enable us to perform xenotransplantation we decided to cross two mice mutants: (i) B6SJL-Tg(SOD1*G93A)1Gur/J – ALS model with (ii) B6(Cg)-Rag2tm1.1Cgn/J – immunocompromised mice. Here, SOD1 is linked to amyotrophic lateral sclerosis.