In patients with CKD, mineral and bone disease (MBD) can cause abnormal serum concentration of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and alkaline phosphatase (ALP), resulting in bone-related abnormalities and vascular calcification. The gene discussed is FGF23; the disease is Marchiafava-Bignami disease.