NAPEPLD and Hepatic steatosis: In any case, the fact that NAPE-PLD does not appear to be necessary for A. muciniphila to elicit its beneficial metabolic actions is also confirmed by our finding that administration of the bacterium blunts hyperphagia and HFD-induced hepatic steatosis as well as circulating NEFA in Napepld∆IEC mice, uncovering new mechanisms of action of the bacterium on the metabolism of its host.