SYK and cancer: We found cancer cell supernatant incubation increased the phosphorylation of FcγRIIa, PLCγ, and syk in platelets compared with the culture medium treatment (Fig. 7a) and pretreating platelets with IV.3 Fab reduced the phosphorylation of FcγRIIa, PLCγ, and syk (Fig. 7b), indicating that FcγRIIa-signaling pathway was involved in the activation of platelet induced by the cancer cell supernatant.