It has been reported that αIIbβ3 was essentital for FcγRIIa signaling36, here we found inhibiting FcγRIIa or αIIbβ3 both reduced the expression of CD62P, we hypothesize that there may be some factors in the cancer cell culture supernatant that can affect platelet activity by acting on FcγRIIa. This evidence concerns the gene SELP and cancer.