In addition, RNA­seq datasets from TCGA were analyzed and the results suggested a significantly positive correlation between SP1 expression and that of linc00665 in liver hepatocellular carcinoma (r2 = 0.0212, p = 0.0050), but not in lung squamous cell carcinoma, breast invasive carcinoma, or colon adenocarcinoma (supplementary Figure 6c). Here, SP1 is linked to invasive breast carcinoma.