REG3A and infection: Decreased IL-17E-IL-17RB signaling in GECs impairs their release of CXCL1/2/5/6 and antibacterial protein Reg3a, leading to the reduced CD11b+CD11c− myeloid cell attraction and migration into gastric mucosa; and as a direct result impaired host defense against H. pylori during the early-phase of infection (Fig. 7).