Furthermore, we defined a negative regulatory network involving IL-17E, GECs, IL-17RB, CD11b+CD11c− myeloid cells, and Reg3a in the early-phase of infection, which results in an impaired host defense within the gastric microenvironment, suggesting that IL-17RB may serve as a potential early target for intervening H. pylori infection. This evidence concerns the gene REG3A and infection.