An interesting study has already proposed that plasmalemmal NCX isoforms, in particular NCX2 and NCX3, contribute to mitochondrial Na+/Ca2+ exchanger in human DAergic neurons acting downstream PINK1, a pathway implicated in a recessive form of PD, preventing neuronal death induced by mitochondrial Ca2+ accumulation20. The gene discussed is SLC8A2; the disease is Parkinson disease.