GIGYF1 and cancer: PPPGΦ motifs tend to interact with GYF domain proteins (Kofler and Freund 2006), such as the GIGYF1/2 translational repressors (Kryszke et al. 2016; Peter et al. 2017; Amaya Ramirez et al. 2018) that were described to bind CAF40 in human cancer cells (Ajiro et al. 2009).