The stargazin mouse has a mutation in TARP-2, an auxiliary subunit of AMPA receptors, which causes a general decrease in AMPA receptor function and phenotypes that overlap with Frrs1l mutants, specifically ataxia and impaired coordination (Letts et al., 1998; Menuz and Nicoll, 2008). Here, FRRS1L is linked to cerebellar ataxia.