NFE2L2 and neoplasm: As such, it is worthwhile to note that in a disease setting where NRF2 is high, such as cancer, tumor cells could utilize these protective detoxification systems to prevent lipid peroxide accumulation and lipoxidation of target proteins to survive; whereas in diseases where NRF2 is low, such as neurodegenerative diseases, increased lipoxidation and inactivation of downstream NRF2 targets could significantly enhance overall protein lipoxidation and ferroptosis, furthering disease progression.