As such, it is worthwhile to note that in a disease setting where NRF2 is high, such as cancer, tumor cells could utilize these protective detoxification systems to prevent lipid peroxide accumulation and lipoxidation of target proteins to survive; whereas in diseases where NRF2 is low, such as neurodegenerative diseases, increased lipoxidation and inactivation of downstream NRF2 targets could significantly enhance overall protein lipoxidation and ferroptosis, furthering disease progression. The gene discussed is NFE2L2; the disease is neurodegenerative disease.