However, the etiology of TS is not known and multiple factors including thromboplastin-like substances, fibrin deposition, direct activation of factor X by tumor proteases, tissue factor, cysteine protease, tumor hypoxia, tumor-induced inflammatory cytokines, are believed to be responsible for this phenomenon in murine models [11, 15–18] of mucinous carcinoma. The gene discussed is CTSB; the disease is Timothy syndrome.