FOXO3 and metastatic malignant neoplasm in the lymph nodes: Clinicopathological analyses demonstrated that decreased FOXO3a expression prominently correlated with depth of invasion (P < 0.001), TNM stage (P < 0.001), differentiated degree (P < 0.001), lymph node metastasis (P < 0.001), and distant metastasis (P = 0.044) in patients with PDAC (Table 2).