ZNF326 and neoplasm: In the initial stage of our experiment, we noticed that the opposite results were reported in three negative breast cancers (TNBC) by Rangel et al, who found that the expression of ZNF326 in TNBC specimens was decreased and ZNF326 overexpression was able to weaken the ability of the transplanted tumour formation [35], indicating ZNF326 acts as a tumor suppressor gene.