Notably, we found the glioma cells with co-transfecion of ZNF326 and shRNA-HDAC7 still exerted the higher tumor formation ability compared to the control group, or in vitro, transfection siRNA-HADC7 just partially abolished the promotion effect of ZNF326 in glioma proliferation, which indicates ZNF326 also could promotes glioma progression via HDAC7-independent manner. The gene discussed is ZNF326; the disease is neoplasm.