The recent evidence implicating the JNK signalling pathway, and specifically the kinases involved in JNK activation, such as MKK7 (MAP2K7) [25], ULK4 [26], and VRK2 and TAOK2 [4, 27], in genetic risk for schizophrenia [2, 28] is of particular interest, since MKK7-JNK signalling is not only involved in glutamatergic signalling in the CNS [29], but is also believed to mediate aspects of the innate immune response [30]. The gene discussed is MAPK8; the disease is schizophrenia.