As shown in Table 7, according to multivariate analysis, FN+/αvβ3+ independently predicted worse DFS (hazard ratio (HR) = 2.66, P = 0.025, C-index = 0.75) and OS (HR = 3.75, P = 0.011, C-index = 0.84) of patients with osteosarcoma compared with other groups (FN+/αvβ3− plus FN−/αvβ3+ plus FN−/αvβ3−). This evidence concerns the gene FN1 and osteosarcoma.