SOX2 and neoplasm: We demonstrated that CDH11 knockdown significantly reduces the size of formed mammospheres, with concomitant downregulation of CSCs markers, Sox2, KLF4, CD44, and c-Myc (Figure 5), which is consistent with previous findings showing that inhibition of the canonical WNT signalling decreased Sox2 [36], CD44 [24], and c-Myc, as well as suppressed tumorsphere formation and inhibited tumor formation in xenograft tumor mice models [34,37].