Au contraire, treatment with VPA significantly stimulates migration and invasion in vitro, argubly by activation of EMT in HCT116 and SW480 human colorectal cancer cell lines, resulting in downregulating the epithelial markers: E-cadherin and ZO-1 and upregulating the mesenchymal markers: N-cadherin and fibronectin in both HCT116 and SW480 cells as well as upregulating the vimentin only in HCT116 cells. The gene discussed is VIM; the disease is colorectal cancer.