Using a colitis-associated CRC mouse model, Ma et al. reported that prostaglandin E2 receptor subtype EP2 was expressed in infiltrating TANs and CAFs in CRC, and that the expression of cytokines such as TNF-α, IL-6, CXCL1, cyclooygenase-2, and Wnt5A was amplified in tumor lesions via EP2 expression in TANs and CAFs. Here, WNT5A is linked to colorectal carcinoma.