Neutrophils are known to secrete several inflammatory, immunoregulatory, and angiogenic factors, including neutrophil elastase [34], matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF) [35,36], and hepatocyte growth factor [37], which can exhibit paracrine effects on the tumor microenvironment. The gene discussed is VEGFA; the disease is neoplasm.