SOD2 and neuroblastoma: SH-SY5Y neuroblastoma cells stably expressing TRPM2-L showed enhanced protection against cell death induced by oxidative stress via increased forkhead box transcription factor 3a (FOXO3a) and superoxide dismutase 2 (SOD2) levels, while cells expressing TRPM2-S showed enhanced levels of ROS and reduced cell viability [79,80].