A number of TRP-melastatin (TRPM) channels have been implicated in glioblastoma progression: reactive oxygen species (ROS)-activated TRPM2 channel induces cell death in A172 human glioblastoma cells [59]; TRPM7 channel promotes proliferation and migration of A172 cells possibly through activation of JAK2/STAT3 and Notch signaling pathways [60]; and TRPM8 channel, via activation of the large-conductance Ca2+-activated K+ membrane ion channels (BK channels), regulates migration of DBTRG glioblastoma cells [61,62]. The gene discussed is STAT3; the disease is glioblastoma.