Additionally, the administration of high-dose vitamin C in Gulo KO mice with a 5XFAD mice background (a cross-bred between an AD mice model and mice unable to produce vitamin C) resulted in reduced amyloid plaques in hippocampal and cortical regions; and short-term high-dose infusion enhanced spatial learning and memory in APP/PSEN1 and wild-type mice [90]. Here, APP is linked to Alzheimer disease.