BACE1 and Alzheimer disease: Moreover, vitamin A and its derivatives have demonstrated a transcription-regulating effect on several genes related to AD in vitro and in vivo, such as ADAM9 and ADAM10, APP, or BACE, among others [76,86,87,88]; as well as a potential role in reducing histone acetylation through its antioxidant properties, which may be also attributable to vitamins C and E [74].