APP and Alzheimer disease: This accords with previous results showing that female transgenic mice model of AD Tg2576 overexpressing the human APP with the Swedish mutation (K670N/M671L) that were fed a diet low in folic acid (<0.2 mg/kg), vitamin B12 (<0.001 mg/kg), and vitamin B6 (<0.1 mg/kg) displayed hyperhomocysteinemia, which caused an increase in Aβ as a consequence of enhanced γ-secretase activity [104].