TNKS and small cell lung carcinoma: On the other hand, we did not observe any effect of XAV939 on TGF-β induced EMT in NMuMG cells, despite the fact that TNKS inhibition by XAV939 and the subsequent modulation of WNT pathway inhibits the proliferation of small-cell lung cancer H446 cells as well as proliferation and migration of lung adenocarcinoma A549 cells [47,48].